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Bourikas, Dimitris; Pekarik, Vladimir; Baeriswyl, T; Grunditz, A; Sadhu, R; Nardó, M; Stoeckli, E T (2005). Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Nature Neuroscience, 8(3):297-304.

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Abstract

Dorsal commissural axons in the developing spinal cord cross the floor plate, then turn rostrally and grow along the longitudinal axis, close to the floor plate. We used a subtractive hybridization approach to identify guidance cues responsible for the rostral turn in chicken embryos. One of the candidates was the morphogen Sonic hedgehog (Shh). Silencing of the gene SHH (which encodes Shh) by in ovo RNAi during commissural axon navigation demonstrated a repulsive role in post-commissural axon guidance. This effect of Shh was not mediated by Patched (Ptc) and Smoothened (Smo), the receptors that mediate effects of Shh in morphogenesis and commissural axon growth toward the floor plate. Rather, functional in vivo studies showed that the repulsive effect of Shh on postcommissural axons was mediated by Hedgehog interacting protein (Hip).

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:1 March 2005
Deposited On:11 Feb 2008 12:13
Last Modified:27 Nov 2013 18:13
Publisher:Nature Publishing Group
ISSN:1097-6256
Publisher DOI:10.1038/nn1396
PubMed ID:15746914
Citations:Web of Science®. Times Cited: 113
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Scopus®. Citation Count: 119

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