Goswami, N; Higginbotham, C; Volkert, W A; Alberto, R; Nef, W; Jurisson, S (1999). Rhodium-105 tetrathioether complexes: radiochemistry and initial biological evaluation. Nuclear Medicine and Biology, 26(8):951-957.
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105Rhodium(III) complexes with three different acyclic tetrathioether ligands containing pendant carboxylic acid groups have been synthesized and characterized. The complexes were evaluated for stability under physiological conditions and the most promising complexes were evaluated in vivo in normal mice. The primary route of clearance for these complexes was the renal/urinary system, consistent with the presence of pendant carboxylate groups. The results indicate that the cis-[Rh(III)Cl2(2,5,8,11-tetrathiadodecane-1,12-dicarboxylic acid)]+ complex shows the most promising in vivo characteristics on which to base a potential therapeutic radiopharmaceutical.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Date:||1 November 1999|
|Deposited On:||11 Feb 2008 12:25|
|Last Modified:||27 Nov 2013 20:19|
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