Hamani, C; McAndrews, M P; Cohn, M; Ohta, M; Zumsteg, D; Shapiro, C M; Wennberg, R A; Lozano, A M (2008). Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Annals of Neurology, 63(1):119-123.
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Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded "on" versus "off" manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology|
|DDC:||610 Medicine & health|
|Deposited On:||02 Mar 2009 13:01|
|Last Modified:||27 Nov 2013 18:14|
|Additional Information:||Full text at http://www3.interscience.wiley.com/cgi-bin/fulltext/117902419/PDFSTART|
|Citations:||Web of Science®. Times Cited: 117|
Scopus®. Citation Count: 141
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