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Hamani, C; McAndrews, M P; Cohn, M; Ohta, M; Zumsteg, D; Shapiro, C M; Wennberg, R A; Lozano, A M (2008). Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Annals of Neurology, 63(1):119-123.

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Abstract

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories. Associative memory tasks conducted in a double-blinded "on" versus "off" manner demonstrated that stimulation increased recollection but not familiarity-based recognition, indicating a functional engagement of the hippocampus. Electroencephalographic source localization showed that hypothalamic deep brain stimulation drove activity in mesial temporal lobe structures. This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions.

Citations

117 citations in Web of Science®
142 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:02 Mar 2009 13:01
Last Modified:27 Nov 2013 18:14
Publisher:Wiley-Blackwell
ISSN:0364-5134
Additional Information:Full text at http://www3.interscience.wiley.com/cgi-bin/fulltext/117902419/PDFSTART
Publisher DOI:10.1002/ana.21295
PubMed ID:18232017

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