Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Spring, R M; Ulrich, S; Huber, L C; Speich, R; Maggiorini, M; Treder, U; Fischler, M (2008). Sildenafil for pulmonary hypertension: dose-dependent improvement in exercise performance. Pulmonary Pharmacology and Therapeutics, 21(3):516-521.

Full text not available from this repository.

View at publisher

Abstract

Sildenafil has been widely used as an orphan drug for several years, mostly at a dose of 50mg tid. Since a recent randomized study showed no dose-response relationship, the target dose in future will be 20mg tid. This might, however, have a negative effect on patients being already on 50mg tid. During the past years we usually up-titrated the sildenafil dosage in monthly intervals from 12.5 to 25mg, and then finally to 50mg tid. Therefore, we wondered if a dose-response relationship could be found in a group of 23 patients, in whom we had measured a 6-min walking distance (6-MWD) at all time points. The 6-MWD was virtually unchanged during the treatment with sildenafil 12.5 and 25mg tid, respectively. However, there was a significant improvement by 34+/-63 and 26+/-47m in the 6-MWD after increasing the sildenafil dose to 50mg tid compared with baseline (p=0.015) and 25mg tid (p=0.014), respectively. In conclusion, these data suggest that sildenafil has a clinically relevant dose-response relationship with a significant improvement in 6-MWD only at a dose of 50mg tid.

Citations

5 citations in Web of Science®
7 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
DDC:610 Medicine & health
Language:English
Date:2008
Deposited On:03 Mar 2009 09:51
Last Modified:27 Nov 2013 20:42
Publisher:Elsevier
ISSN:1094-5539
Publisher DOI:10.1016/j.pupt.2007.11.006
PubMed ID:18249145

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page