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Biophysical parameters modification could overcome essential hearing gaps


Kern, A; Heid, C; Steeb, W H; Stoop, N; Stoop, R (2008). Biophysical parameters modification could overcome essential hearing gaps. PLoS Computational Biology, 4(8):e1000161.

Abstract

A majority of hearing defects are due to malfunction of the outer hair cells (OHCs), those cells within the mammalian hearing sensor (the cochlea) that provide an active amplification of the incoming signal. Malformation of the hearing sensor, ototoxic drugs, acoustical trauma, infections, or the effect of aging affect often a whole frequency interval, which leads to a substantial loss of speech intelligibility. Using an energy-based biophysical model of the passive cochlea, we obtain an explicit description of the dependence of the tonotopic map on the biophysical parameters of the cochlea. Our findings indicate the possibility that by suitable local modifications of the biophysical parameters by microsurgery, even very salient gaps of the tonotopic map could be bridged.

A majority of hearing defects are due to malfunction of the outer hair cells (OHCs), those cells within the mammalian hearing sensor (the cochlea) that provide an active amplification of the incoming signal. Malformation of the hearing sensor, ototoxic drugs, acoustical trauma, infections, or the effect of aging affect often a whole frequency interval, which leads to a substantial loss of speech intelligibility. Using an energy-based biophysical model of the passive cochlea, we obtain an explicit description of the dependence of the tonotopic map on the biophysical parameters of the cochlea. Our findings indicate the possibility that by suitable local modifications of the biophysical parameters by microsurgery, even very salient gaps of the tonotopic map could be bridged.

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2 citations in Web of Science®
2 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:August 2008
Deposited On:07 Mar 2009 21:21
Last Modified:09 Aug 2016 09:06
Publisher:Public Library of Science (PLoS)
ISSN:1553-734X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1371/journal.pcbi.1000161
PubMed ID:18769713
Permanent URL: http://doi.org/10.5167/uzh-17636

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