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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-17722

Andreisek, G; White, L M; Kassner, A; Tomlinson, G; Sussman, M S (2009). Diffusion tensor imaging and fiber tractography of the median nerve at 1.5T: optimization of b value. Skeletal Radiology, 38(1):51-59.

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OBJECTIVE: The objective of this study was to systematically assess the optimal b value for diffusion tensor imaging and fiber tractography of the median nerve at 1.5 T. MATERIALS AND METHODS: This is a prospective study which was carried out with institutional review board approval and written informed consent from the study subjects. Fifteen healthy volunteers (seven men, eight women; mean age, 31.2 years) underwent diffusion tensor imaging of the wrist. A single-shot spin-echo-based echo-planar imaging sequence (TR/TE, 7000/103 ms) was performed in each subject at eight different b values ranging from 325 to 1,550 s/mm(2). Number and length of reconstructed fiber tracts, fiber density index (FDi), fractional anisotropy (FA), and apparent diffusion coefficient (ADC) were calculated for the median nerve. Signal-to-noise ratio (SNR) was also calculated for each acquisition. The overall image quality was assessed by two readers in consensus by ranking representative fiber tract images for each subject using a scale range from 1 to 8 (1 = best to 8 = worst image quality). RESULTS: Longest fibers were observed for b values between 675 and 1,025 s/mm(2). Maximum FDi was found at b values of 1,025 s/mm(2). FA was between 0.5 and 0.6 for all b values. ADC gradually decreased from 1.44 x 10(-3) to 0.92 x 10(-3) mm(2)/s with increasing b values. Maximum SNR +/- standard deviation (175.4 +/- 72.6) was observed at the lowest b value and decreased with increasing b values. SNR at b values of 1,025 s/mm(2) was 48.5% of the maximum SNR. Optimal fiber tract image quality was found for b values of 1,025 s/mm(2). CONCLUSIONS: The optimal b value for diffusion tensor imaging and fiber tractography of the median nerve at 1.5 T was 1,025 s/mm(2).


29 citations in Web of Science®
36 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Deposited On:11 Mar 2009 16:16
Last Modified:05 Apr 2016 13:10
Publisher DOI:10.1007/s00256-008-0577-6
PubMed ID:18773203

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