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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-17763

Husmann, L; Gaemperli, O; Valenta, I; Schepis, T; Scheffel, H; Stolzmann, P; Leschka, S; Desbiolles, L; Marincek, B; Alkadhi, H; Kaufmann, P A (2009). Impact of vessel attenuation on quantitative coronary angiography with 64-slice computed tomography. British Journal of Radiology, 82(980):649-653.

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The aim of the study was to determine the impact of vessel attenuation on quantitative 64-slice computed tomography coronary angiography (CTCA). CTCA and invasive quantitative coronary angiography (QCA) were performed in 100 consecutive patients (42 women, 58 men; mean age 64.4+/-9.4 years; age range 39-87 years). In QCA, stenoses were quantified with dedicated software, whereas in CTCA, stenosis severity was assessed with an electronic caliper tool: stenoses were graded in 10% steps and assigned as either a calcified or non-calcified lesion. Vessel attenuation in the left main (LMA) and the proximal right coronary artery (RCA) were measured and correlated with differences in quantifications of stenosis grade between QCA and CTCA. A total of 113 coronary stenoses were detected by both methods (94 significant and 19 non-significant); 52 stenoses were rated as non-calcified and 61 as calcified lesions. The mean difference between QCA and quantitative CTCA grading was 5.1+/-16.9% (range -27 to 46%) overall; 1.9+/-14.2% (range -27 to 38%) for non-calcified lesions and 7.8+/-18.6% (range -23 to 46%) for calcified lesions. Mean vessel attenuation was 362+/-76 HU (range 191 to 584 HU) in the LMA and 333+/-81 HU (range 162 to 564 HU) in the RCA. Attenuation did not significantly correlate with differences in QCA and CTCA gradings; neither overall, nor for calcified or non-calcified lesions. When 64-slice CTCA is used, coronary vessel attenuation had no impact on the quantitative grading of stenoses.


4 citations in Web of Science®
5 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:16 February 2009
Deposited On:18 Mar 2009 07:24
Last Modified:05 Apr 2016 13:10
Publisher:British Institute of Radiology
Publisher DOI:10.1259/bjr/40319502
Official URL:http://bjr.birjournals.org/cgi/content/abstract/40319502v1
PubMed ID:19221184

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