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Aguzzi, A; Brandner, S; Marino, S; Steinbach, J P (1996). Transgenic and knockout mice in the study of neurodegenerative diseases. Journal of Molecular Medicine, 74(3):111-126.

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Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Feb 2008 12:25
Last Modified:27 Nov 2013 19:44
Publisher DOI:10.1007/BF01575443
Related URLs:http://springerlink.metapress.com/content/mh66pccrrb7n4bfv/
PubMed ID:8846161
Citations:Web of Science®. Times Cited: 29
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