Aguzzi, A; Brandner, S; Marino, S; Steinbach, J P (1996). Transgenic and knockout mice in the study of neurodegenerative diseases. Journal of Molecular Medicine, 74(3):111-126.
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Abstract
Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological conditions of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
| Item Type: | Journal Article, refereed |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 1996 |
| Deposited On: | 11 Feb 2008 13:25 |
| Last Modified: | 23 Nov 2012 17:09 |
| Publisher: | Springer |
| ISSN: | 0946-2716 |
| Related URLs: | http://springerlink.metapress.com/content/mh66pccrrb7n4bfv/ |
| PubMed ID: | 8846161 |
| WoS Citation Count: | 27 |
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