Abstract

The absorption of amino acids from the diet across small intestine enterocytes and the reabsorption of amino acids from the kidney glomerular filtrate are critical features that allow maintenance of the body’s amino acid supply. Altogether, our results show that B0AT1 (Slc6a19) expression is controlled by tissue-specific associated proteins Collectrin (Tmem27) in kidney and angiotensin-converting enzyme 2 (ACE2) in small intestine. ACE2 has, in contrast to Collectrin, a catalytic domain and plays a key role in the renin angiotensin system. Our results indicate that the formerly orphan transporter XT2 (Slc6a18), that we renamed B0AT3, functions as a Na+ and Cl--dependent neutral amino acid transporter associated to Collectrin in the kidney.