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Role of orphan amino acid transporters and interacting proteins studied in mouse models


Singer, D. Role of orphan amino acid transporters and interacting proteins studied in mouse models. 2009, University of Zurich, Faculty of Science.

Abstract

The absorption of amino acids from the diet across small intestine enterocytes and the reabsorption of amino acids from the kidney glomerular filtrate are critical features that allow maintenance of the body’s amino acid supply. Altogether, our results show that B0AT1 (Slc6a19) expression is controlled by tissue-specific associated proteins Collectrin (Tmem27) in kidney and angiotensin-converting enzyme 2 (ACE2) in small intestine. ACE2 has, in contrast to Collectrin, a catalytic domain and plays a key role in the renin angiotensin system. Our results indicate that the formerly orphan transporter XT2 (Slc6a18), that we renamed B0AT3, functions as a Na+ and Cl--dependent neutral amino acid transporter associated to Collectrin in the kidney.

The absorption of amino acids from the diet across small intestine enterocytes and the reabsorption of amino acids from the kidney glomerular filtrate are critical features that allow maintenance of the body’s amino acid supply. Altogether, our results show that B0AT1 (Slc6a19) expression is controlled by tissue-specific associated proteins Collectrin (Tmem27) in kidney and angiotensin-converting enzyme 2 (ACE2) in small intestine. ACE2 has, in contrast to Collectrin, a catalytic domain and plays a key role in the renin angiotensin system. Our results indicate that the formerly orphan transporter XT2 (Slc6a18), that we renamed B0AT3, functions as a Na+ and Cl--dependent neutral amino acid transporter associated to Collectrin in the kidney.

Additional indexing

Item Type:Dissertation
Referees:Verrey F, Wagner C A, Montani J P
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:08 Apr 2009 10:05
Last Modified:05 Apr 2016 13:11
Number of Pages:120

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