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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-17933

Zeilhofer, H U; Witschi, R; Hösl, K (2009). Subtype-selective GABA(A) receptor mimetics-novel antihyperalgesic agents? Journal of Molecular Medicine, 87(5):465-469.

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Abstract

Agonists at the benzodiazepine-binding site of ionotropic gamma-aminobutyric acid (GABA(A)) receptors are in clinical use as hypnotics, anxiolytics, and anticonvulsants since the early 1960. Analgesic effects of classical benzodiazepines have occasionally been reported in certain subgroups of patients suffering from chronic pain or after spinal delivery through intrathecal catheters. However, these drugs are generally not considered as analgesics but should in fact be avoided in patients with chronic pain. Recent evidence from genetically modified mice now indicates that agents targeting only a subset of benzodiazepine (GABA(A)) receptors should provide pronounced antihyperalgesic activity against inflammatory and neuropathic pain. Several such compounds have been developed recently, which exhibit significant antihyperalgesia in mice and rats and appear to be devoid of the typical side-effects of classical benzodiazepines.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:May 2009
Deposited On:13 Jul 2009 08:51
Last Modified:27 Nov 2013 21:14
Publisher:Springer
ISSN:0946-2716
Publisher DOI:10.1007/s00109-009-0454-3
PubMed ID:19259638
Citations:Web of Science®. Times Cited: 13
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