Gandy, S; DeMattos, R B; Lemere, C A; Heppner, F L; Leverone, J; Aguzzi, A; Ershler, W B; Dai, J; Fraser, P; Hyslop, P S; Holtzman, D M; Walker, L C; Keller, E T (2004). Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta). Alzheimer Disease and Associated Disorders, 18(1):44-46.
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Recent preliminary data suggest that vaccination with Alzheimer A beta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-A beta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated A beta 1-42. Immunized monkeys developed anti-A beta titers exceeding 1:1000, and their plasma A beta levels were 5- to 10-fold higher than the plasma A beta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer A beta.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||11 Feb 2008 12:25|
|Last Modified:||28 Nov 2013 00:53|
|Publisher:||Lippincott Wiliams & Wilkins|
|Citations:||Web of Science®. Times Cited: 16|
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