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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-18086

Strobel, K; Skalsky, J; Steinert, H C; Dummer, R; Hany, T F; Bhure, U; Seifert, B; Pérez Lago, M; Joller-Jemelka, H; Kalff, V (2007). S-100B and FDG-PET/CT in therapy response assessment of melanoma patients. Dermatology, 215(3):192-201.

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Abstract

OBJECTIVE: To compare the value of the tumor marker S-100B protein and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in patients treated for melanoma metastases.

METHODS: In 41 patients with proven melanoma metastases, S-100B measurements and FDG-PET/CT were performed before and after therapy. The change of S-100B levels (DeltaS-100B) was assessed. In all patients, therapy response was assessed with PET/CT using visual criteria and change of maximal standard uptake value (DeltaSUV(max.)) or total lesion glycolysis (DeltaTLG).

RESULTS: In 15 of 41 patients (37%), S-100B values were not suitable because they were normal before and after therapy. In 26 patients, S-100B was suitable for therapy response assessment. PET/CT was suitable for response assessment in all patients. Correlations between DeltaS-100B and DeltaTLG (r = 0.850, p < 0.001) and between DeltaS-100B and DeltaSUV(max.) (r = 0.818, p < 0.001) were both excellent. A complete agreement between S-100B and PET/CT response assessment was achieved in 22 of 26 patients. In 4 patients, therapy response differed between the S-100B and PET/CT findings, but subsequent S-100B measurements realigned the S-100B results with the later PET/CT findings.

CONCLUSION: In a third of our patients with metastases, the S-100B tumor marker was not suitable for therapy assessment. In these patients, imaging techniques remain necessary, and FDG-PET/CT can be used for response assessment.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > Institute of Social and Preventive Medicine
DDC:610 Medicine & health
Language:English
Date:2007
Deposited On:14 Apr 2009 06:30
Last Modified:27 Nov 2013 17:15
Publisher:Karger
ISSN:1018-8665
Publisher DOI:10.1159/000106575
PubMed ID:17823514
Citations:Web of Science®. Times Cited: 18
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Scopus®. Citation Count: 18

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