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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1820

Frigg, R; Klein, M A; Hegyi, I; Zinkernagel, R M; Aguzzi, A (1999). Scrapie pathogenesis in subclinically infected B-cell-deficient mice. Journal of Virology, 73(11):9584-9588.



Prion infections can present without clinical manifestations. B-cell deficiency may be a model for subclinical transmissible spongiform encephalopathy, since it protects mice from disease upon intraperitoneal administration of scrapie prions; however, a proportion of B-cell-deficient mice accumulate protease-resistant prion protein in their brains. Here, we have characterized this subclinical disease. In addition, we have studied the possibility that a neurotoxic factor secreted by B cells may contribute to pathogenesis.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Date:1 November 1999
Deposited On:11 Feb 2008 12:25
Last Modified:27 Nov 2013 23:50
Publisher:American Society for Microbiology
Related URLs:http://jvi.asm.org/cgi/content/full/73/11/9584?view=long&pmid=10516067
PubMed ID:10516067
Citations:Web of Science®. Times Cited: 67
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