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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-18207

Venzin, R M; Cohen, C D; Maggiorini, M; Wüthrich, R P (2009). Aliskiren-associated acute renal failure with hyperkalemia. Clinical Nephrology, 71(3):326-328.

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We report the first case of acute renal failure with hyperkalemia associated with the recently marketed direct renin inhibitor aliskiren. To optimize blood pressure control, the antihypertensive medication of a 76-year-old hypertensive female patient was changed from the angiotensin II receptor antagonist irbesartan to aliskiren. Spironolactone was continued, as serum creatinine and potassium levels were initially normal. Two weeks later the patient presented with acute oliguric renal failure, symptomatic hyperkalemia and metabolic acidosis, necessitating emergency dialytic treatment. Unrecognized pre-existing renal insufficiency (CKD Stage 2 - 3) and the continuation of spironolactone were identified as predisposing risk factors.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
DDC:610 Medicine & health
Date:March 2009
Deposited On:14 Apr 2009 08:59
Last Modified:27 Nov 2013 23:25
Publisher:Dustri-Verlag Dr Karl Feistle
PubMed ID:19281746
Citations:Web of Science®. Times Cited: 8
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Scopus®. Citation Count: 9

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