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Klein, M A; Frigg, R; Raeber, A J; Flechsig, E; Hegyi, I; Zinkernagel, R M; Weissmann, C; Aguzzi, A (1998). PrP expression in B lymphocytes is not required for prion neuroinvasion. Nature Medicine, 4(12):1429-1433.

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Abstract

Prion diseases are typically initiated by infection of peripheral sites, as in the case of bovine spongiform encephalopathy, new variant Creutzfeldt-Jakob disease, kuru and most cases of iatrogenic Creutzfeldt-Jakob disease. In mouse scrapie, prion infectivity accumulates in lymphoid organs, and the absence of mature B lymphocytes prevents peripherally administered prions from inducing central nervous system disease. We have now assessed whether expression of the cellular prion protein, PrPc, is required for B lymphocytes to mediate neuroinvasion. We found that repopulation of SCID and Rag-1(-/-) mice with fetal liver cells from either PrP-expressing or PrP-deficient mice and from T-cell deficient mice, but not from B-cell deficient mice, is equally efficient in restoring neuroinvasion after intraperitoneal inoculation of scrapie prions. These results indicate that cells whose maturation depends on B cells or their products, such as follicular dendritic cells, may enhance neuroinvasion. Alternatively, B cells may transport prions to the nervous system by a PrP-independent mechanism.

Citations

208 citations in Web of Science®
204 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 December 1998
Deposited On:11 Feb 2008 12:25
Last Modified:27 Nov 2013 21:42
Publisher:Nature Publishing Group
ISSN:1078-8956
Publisher DOI:10.1038/4022
PubMed ID:9846583

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