Bieniasz, P D; Erlwein, O; Aguzzi, A; Rethwilm, A; McClure, M O (1997). Gene transfer using replication-defective human foamy virus vectors. Virology, 235(1):65-72.
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Abstract
Replication-defective vectors based on an infectious molecular clone of human foamy virus (HFV) were constructed by deletion and replacement of the accessory genes with expression cassettes for puromycin-resistance and beta-glucouronidase. Cell lines which produced in excess of 10(5) helper virus-free transducing units/ml were generated by trans-complementation of the replication defect using a BHK-21-derived cell line expressing the Bel-1 transactivator. Vectors based on the HFV genome may provide useful alternatives to existing retroviral vectors.
| Item Type: | Journal Article, refereed |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 18 August 1997 |
| Deposited On: | 11 Feb 2008 13:25 |
| Last Modified: | 23 Nov 2012 16:11 |
| Publisher: | Elsevier |
| ISSN: | 0042-6822 |
| Publisher DOI: | 10.1006/viro.1997.8658 |
| PubMed ID: | 9300037 |
| WoS Citation Count: | 25 |
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