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Bieniasz, P D; Erlwein, O; Aguzzi, A; Rethwilm, A; McClure, M O (1997). Gene transfer using replication-defective human foamy virus vectors. Virology, 235(1):65-72.

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Abstract

Replication-defective vectors based on an infectious molecular clone of human foamy virus (HFV) were constructed by deletion and replacement of the accessory genes with expression cassettes for puromycin-resistance and beta-glucouronidase. Cell lines which produced in excess of 10(5) helper virus-free transducing units/ml were generated by trans-complementation of the replication defect using a BHK-21-derived cell line expressing the Bel-1 transactivator. Vectors based on the HFV genome may provide useful alternatives to existing retroviral vectors.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:18 August 1997
Deposited On:11 Feb 2008 12:25
Last Modified:27 Nov 2013 21:41
Publisher:Elsevier
ISSN:0042-6822
Publisher DOI:10.1006/viro.1997.8658
PubMed ID:9300037
Citations:Web of Science®. Times Cited: 25
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