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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-18522

Rohrer Bley, Carla; Ohlerth, Stefanie; Roos, Malgorzata; Wergin, Melanie; Achermann, Roger; Kaser-Hotz, Barbara (2006). Influence of pretreatment polarographically measured oxygenation levels in spontaneous canine tumors treated with radiation therapy. Strahlentherapie und Onkologie, 182(9):518-524.

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Abstract

BACKGROUND AND PURPOSE: The level of hypoxia in primary tumors has been described to influence response to treatment. The aim of the present study was to investigate the impact of pretreatment oxygen level measurements in spontaneous canine tumors on treatment outcome. MATERIALS AND METHODS: Data of pretreatment tumor oxygenation status and local tumor response after primary radiation therapy in a group of spontaneously occurring tumors in dogs (n=52) was collected. Radiation therapy was given with curative (14-17x3-3.5 Gy) or palliative intent (3x8 Gy or 4-5x6 Gy). Progression-free interval and overall survival were correlated to polarographically measured tumor oxygenation status. RESULTS: In the curatively irradiated group, tumors with median pO2 values<or=10 mmHg tended to have shorter median progression- free interval compared to better oxygenated tumors (246 vs. 739 days). The same trend could be shown for overall survival (330 vs. 745 days), indicating a cutoff value in this region. In the group treated with lower doses of radiation, the level of oxygen was no longer found to be of prognostic value; however, in this group hemoglobin had a significant impact on outcome. CONCLUSION: In curatively irradiated spontaneous canine tumors, tumor hypoxia was found to be a prognostic indicator, independent of tumor histologies and volume.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemology, Biostatistics and Prevention Institute (EBPI)
DDC:610 Medicine & health
Date:September 2006
Deposited On:13 May 2009 15:38
Last Modified:27 Nov 2013 23:22
Publisher:Springer
ISSN:0179-7158
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00066-006-1519-7
PubMed ID:16944373
Citations:Web of Science®. Times Cited: 7
Google Scholar™
Scopus®. Citation Count: 10

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