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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-18523

Ohlerth, Stefanie; Laluhová, Dagmar; Buchholz, Julia; Roos, Malgorzata; Walt, Heinrich; Kaser-Hotz, Barbara (2006). Changes in vascularity and blood volume as a result of photodynamic therapy can be assessed with power Doppler ultrasonography. Lasers in Surgery and Medicine, 38(3):229-234.

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BACKGROUND AND OBJECTIVES: One principal mechanism of photodynamic therapy (PDT) in tumors is destruction of tumor-associated vasculature. In the present study, the vascular effects of PDT in tumors were investigated with power Doppler ultrasonography. MATERIALS AND METHODS: Seven cutaneous squamous cell carcinomas in cats were treated. Tumors were examined via power Doppler ultrasonography before, 5 minutes, 1 hour, and 24 hours after PDT. Images were digitized for computer-aided assessment of vascularity and blood volume. RESULTS: Mean baseline tumor vascularity and blood volume were moderate. During PDT, a significant decrease in vascularity and blood volume was noted. Lowest values were found 24 hours after PDT. CONCLUSIONS: Power Doppler ultrasonography represents a non-invasive modality to successfully monitor the vascular effects and thus, treatment efficacy, of PDT.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Social and Preventive Medicine
DDC:610 Medicine & health
Date:03 January 2006
Deposited On:13 May 2009 17:51
Last Modified:27 Nov 2013 18:04
Publisher DOI:10.1002/lsm.20282
PubMed ID:16392148
Citations:Web of Science®. Times Cited: 11
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