Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1854
Schmidt, M; Niewiesk, S; Heeney, J; Aguzzi, A; Rethwilm, A (1997). Mouse model to study the replication of primate foamy viruses. Journal of General Virology, 78(8):1929-1933.
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A mouse model was developed to study the virus-host interaction of molecularly cloned human foamy virus (HFV) in vivo. The infectious process was analysed in two mouse strains, CBA/Ca and C57BL/6J, over a period of 24 weeks by PCR on DNAs from various animal tissues; virus serology was examined by immunoblotting. The infection persisted in both mouse strains and did not induce clinical symptoms. Upon infection of adult CBA/Ca mice HFV became detectable by PCR in an increasing number of organs over time. In contrast, in C57BL/6J mice, after an initial phase of dissemination, viral DNA sequences were found only in a few organs. Interestingly, the different course of infection was accompanied by differences in the antiviral immune response. In particular, C57BL/6J mice were high responders with respect to antibodies to the viral Bet protein, while CBA/Ca mice were low responders.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Date:||1 August 1997|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||06 Sep 2015 11:31|
|Publisher:||Society for General Microbiology|
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