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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1854

Schmidt, M; Niewiesk, S; Heeney, J; Aguzzi, A; Rethwilm, A (1997). Mouse model to study the replication of primate foamy viruses. Journal of General Virology, 78(8):1929-1933.

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Abstract

A mouse model was developed to study the virus-host interaction of molecularly cloned human foamy virus (HFV) in vivo. The infectious process was analysed in two mouse strains, CBA/Ca and C57BL/6J, over a period of 24 weeks by PCR on DNAs from various animal tissues; virus serology was examined by immunoblotting. The infection persisted in both mouse strains and did not induce clinical symptoms. Upon infection of adult CBA/Ca mice HFV became detectable by PCR in an increasing number of organs over time. In contrast, in C57BL/6J mice, after an initial phase of dissemination, viral DNA sequences were found only in a few organs. Interestingly, the different course of infection was accompanied by differences in the antiviral immune response. In particular, C57BL/6J mice were high responders with respect to antibodies to the viral Bet protein, while CBA/Ca mice were low responders.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:01 August 1997
Deposited On:11 Feb 2008 13:26
Last Modified:28 Nov 2013 00:49
Publisher:Society for General Microbiology
ISSN:0022-1317
Related URLs:http://vir.sgmjournals.org/cgi/reprint/78/8/1929
PubMed ID:9266990
Citations:Web of Science®. Times Cited: 23
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