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Non-erythroid effects of erythropoietin: Are neutrophils a target?


Avneon, M; Lifshitz, L; Katz, O; Prutchi-Sagiv, S; Gassmann, M; Mittelman, M; Neumann, D (2009). Non-erythroid effects of erythropoietin: Are neutrophils a target? Leukemia Research, 33(10):1430-1432.

Abstract

We have previously shown that erythropoietin (EPO) potentiates the immune response. Analysis of various possible cellular mediators was performed on EPO-injected mice and transgenic mice overexpressing human EPO (tg6). Here we present our studies on neutrophils, peritoneal (casein induced), and from the peripheral blood, spleen and bone marrow. Neutrophil counts were elevated in peripheral blood and spleens of the tg6 mice, yet, no other EPO-associated effects were detected in the count and function of the different neutrophil populations. Hence, neutrophils are probably not mediators of the EPO immunological effects, although their counts may be affected by extreme EPO levels.

We have previously shown that erythropoietin (EPO) potentiates the immune response. Analysis of various possible cellular mediators was performed on EPO-injected mice and transgenic mice overexpressing human EPO (tg6). Here we present our studies on neutrophils, peritoneal (casein induced), and from the peripheral blood, spleen and bone marrow. Neutrophil counts were elevated in peripheral blood and spleens of the tg6 mice, yet, no other EPO-associated effects were detected in the count and function of the different neutrophil populations. Hence, neutrophils are probably not mediators of the EPO immunological effects, although their counts may be affected by extreme EPO levels.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Physiology
04 Faculty of Medicine > Center for Integrative Human Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:17 October 2009
Deposited On:02 Jun 2009 09:30
Last Modified:05 Apr 2016 13:14
Publisher:Elsevier
ISSN:0145-2126
Additional Information:Elsevier - full text article
Publisher DOI:10.1016/j.leukres.2009.03.020
PubMed ID:19376577
Permanent URL: http://doi.org/10.5167/uzh-18740

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