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Genexpressionsanalysen an Nierenbiopsien: Die Europäische Renale cDNA Bank – Kröner-Fresenius Biopsiebank


Cohen, C D; Kretzler, M (2009). Genexpressionsanalysen an Nierenbiopsien: Die Europäische Renale cDNA Bank – Kröner-Fresenius Biopsiebank. Der Pathologe, 30(2):101-104.

Abstract

Die Nierenbiopsie und deren histologische Aufarbeitung sind klinische Routine und diagnostischer Goldstandard in der Nephrologie.Neue Methoden ermöglichen an dem gewonnenen Material neben der etablierten Diagnostik auch die umfassende Analyse der Genexpression. Anhand von Ergebnissen einer europäischen Multicenterstudie zur Genexpressionsanalyse an Nierenbiopsien wird gezeigt, dass dieser moderne Ansatz nicht nur die sogenannte Grundlagenforschung bereichert, sondern in Zukunft die Biopsiediagnostik ergänzen könnte. Die Ziele sind hierbei erweiterte Diagnosestellung, spezifischere Therapieentscheidung und individuelle Prognoseabschätzung. = Histological analysis of kidney biopsies is an essential part of our current diagnostic workup of patients with renal disease. Besides the already established diagnostic tools, new methods allow extensive analysis of the sample tissue’s gene expression. Using results from a European multicenter study on gene expression analysis of renal biopsies, in this review we demonstrate that this novel approach not only expands the scope of so-called basic research but also might supplement future biopsy diagnostics. The goals are improved diagnosis and more specific therapy choice and prognosis estimates.

Die Nierenbiopsie und deren histologische Aufarbeitung sind klinische Routine und diagnostischer Goldstandard in der Nephrologie.Neue Methoden ermöglichen an dem gewonnenen Material neben der etablierten Diagnostik auch die umfassende Analyse der Genexpression. Anhand von Ergebnissen einer europäischen Multicenterstudie zur Genexpressionsanalyse an Nierenbiopsien wird gezeigt, dass dieser moderne Ansatz nicht nur die sogenannte Grundlagenforschung bereichert, sondern in Zukunft die Biopsiediagnostik ergänzen könnte. Die Ziele sind hierbei erweiterte Diagnosestellung, spezifischere Therapieentscheidung und individuelle Prognoseabschätzung. = Histological analysis of kidney biopsies is an essential part of our current diagnostic workup of patients with renal disease. Besides the already established diagnostic tools, new methods allow extensive analysis of the sample tissue’s gene expression. Using results from a European multicenter study on gene expression analysis of renal biopsies, in this review we demonstrate that this novel approach not only expands the scope of so-called basic research but also might supplement future biopsy diagnostics. The goals are improved diagnosis and more specific therapy choice and prognosis estimates.

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Additional indexing

Other titles:Gene expression analyses of kidney biopsies: The European Renal cDNA Bank – Kröner-Fresenius Biopsy Bank
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:German
Date:March 2009
Deposited On:03 Jun 2009 07:19
Last Modified:05 Apr 2016 13:14
Publisher:Springer
ISSN:0172-8113
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00292-008-1111-2
Official URL:http://www.springerlink.com/content/a3773u233448652w/fulltext.pdf
Related URLs:https://www.zora.uzh.ch/2826/
Permanent URL: http://doi.org/10.5167/uzh-18750

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