Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Stuart, E T; Kioussi, C; Aguzzi, A; Gruss, P (1995). PAX5 expression correlates with increasing malignancy in human astrocytomas. Clinical Cancer Research, 1(2):207-214.

Full text not available from this repository.


Rearrangements concerning chromosome 9p are a late event in the progression of human astrocytic tumors to their most malignant form. The expression of PAX5, which maps to chromosome 9p13, was studied in primary human brain tumors of astrocytic origin. Whereas murine Pax5 is not expressed in the forebrain at any stage, PAX5 expression was increased in a range of astrocytomas (WHO grades II-IV) which originated in the forebrain. Expression of PAX5 was limited to those cells which also expressed the oncogenes myc, fos, or jun singularly or in combination. The epidermal growth factor receptor was highly expressed in glioblastoma multiform tumors in areas which were also highly PAX5 positive. We conclude that the missappropriate expression of PAX5 may aid in promoting the progression of astrocytomal malignancy.


63 citations in Web of Science®
62 citations in Scopus®
Google Scholar™

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:1 February 1995
Deposited On:11 Feb 2008 12:26
Last Modified:05 Apr 2016 12:20
Publisher:American Association for Cancer Research
Related URLs:http://clincancerres.aacrjournals.org/cgi/content/abstract/1/2/207
PubMed ID:9815975

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page