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Genoud, N; Behrens, A; Arrighi, I; Aguzzi, A (2003). Prion proteins and infertility: insight from mouse models. Cytogenetic and Genome Research, 103(3-4):285-289.

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Abstract

A wealth of evidence points to an abnormal form of the prion protein called PrP(Sc) as the transmissible agent responsible for prion diseases. However, the physiological function of its normal conformer, the cellular prion protein (PrP(C)), is still unknown. Recently, a homologue of PrP(C) was discovered and denoted Doppel (Dpl). In contrast to PrP, mice deficient for Dpl suffer from an important pathological phenotype: male sterility. This phenotype shifts the attention from the brain, where most of the investigations on Dpl have been performed, to testis, raising hope to resolve the long lasting search of PrP(C) function.

Citations

5 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2003
Deposited On:11 Feb 2008 12:26
Last Modified:27 Nov 2013 19:12
Publisher:Karger
ISSN:1424-8581
Publisher DOI:10.1159/000076814
PubMed ID:15051949

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