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Glatzel, M; Ott, P M; Linder, T; Gebbers, J O; Gmür, A; Wüst, W; Huber, G; Moch, H; Podvinec, M; Stamm, B; Aguzzi, A (2003). Human prion diseases: epidemiology and integrated risk assessment. Lancet Neurology, 2(12):757-763.

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Abstract

Human prion diseases are devastating and incurable, but are very rare. Fears that the bovine spongiform encephalopathy epizootic would lead to a large epidemic of its presumed human counterpart, variant Creutzfeldt-Jakob disease (vCJD), have not been realised. Yet a feeling of uncertainty prevails in the general public and in the biomedical world. The lack of data on the prevalence of asymptomatic carriers of vCJD compounds this uncertainty. In addition to this problem, Switzerland is currently faced with another issue of major public concern: a recent rise in the incidence of CJD. Here we examine the plausibility of several scenarios that may account for the increase in CJD incidence, including ascertainment bias due to improved reporting of CJD, iatrogenic transmission, and transmission of a prion zoonosis. In addition, we present the design and current status of a Swiss population-wide study of subclinical vCJD prevalence.

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 December 2003
Deposited On:11 Feb 2008 12:26
Last Modified:27 Nov 2013 19:02
Publisher:Elsevier
ISSN:1474-4422
Publisher DOI:10.1016/S1474-4422(03)00588-X
Related URLs:http://linkinghub.elsevier.com/retrieve/pii/S147444220300588X
PubMed ID:14636781

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