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Seeger, Harald; Heikenwalder, Mathias; Zeller, Nicolas; Kranich, Jan; Schwarz, Petra; Gaspert, Ariana; Seifert, Burkhardt; Miele, Gino; Aguzzi, Adriano (2005). Coincident scrapie infection and nephritis lead to urinary prion excretion. Science, 310(5746):324-326.

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Abstract

Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand the distribution of prions. We tested whether chronic inflammatory kidney disorders would trigger excretion of prion infectivity into urine. Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation into noninfected indicator mice. Prionuria was found in presymptomatic scrapie-infected and in sick mice, whereas neither prionuria nor urinary PrP(Sc) was detectable in prion-infected wild-type or PrP(C)-overexpressing mice, or in nephritic mice inoculated with noninfectious brain. Thus, urine may provide a vector for horizontal prion transmission, and inflammation of excretory organs may influence prion spread.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:14 October 2005
Deposited On:11 Feb 2008 12:26
Last Modified:02 Dec 2013 09:16
Publisher:American Association for the Advancement of Science (AAAS)
ISSN:0036-8075
Publisher DOI:10.1126/science.1118829
PubMed ID:16224026
Citations:Web of Science®. Times Cited: 106
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