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Glatzel, M; Aguzzi, A (2001). The shifting biology of prions. Brain Research Reviews, 36(2-3):241-248.

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Abstract

Transmissible spongiform encephalopathies (TSEs), or prion diseases, are rare fatal neurodegenerative diseases of humans and animals. Although some TSEs, like scrapie in sheep, have been known to exist for centuries, bovine spongiform encephalopathy (BSE) was recognized only 15 years ago. New variant Creutzfeldt-Jakob disease (nvCJD) of humans is probably caused by consumption of BSE-infected materials. The nature of the infectious agent is not fully elucidated, but substantial evidence suggests that it is devoid of nucleic acids and consists at least in part of an abnormal form of a host protein termed PrP(C). Despite their rarity, prion diseases have become an important topic in public health and basic research because of the connection between nvCJD and BSE and also because of the unusual biological attributes of the infectious agent.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:01 October 2001
Deposited On:11 Feb 2008 13:26
Last Modified:27 Nov 2013 22:31
Publisher:Elsevier
ISSN:0165-0173
Publisher DOI:10.1016/S0165-0173(01)00100-X
PubMed ID:11690621
Citations:Web of Science®. Times Cited: 16
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