Heppner, F L; Musahl, C; Arrighi, I; Klein, M A; Rülicke, T; Oesch, B; Zinkernagel, R M; Kalinke, U; Aguzzi, A (2001). Prevention of scrapie pathogenesis by transgenic expression of anti-prion protein antibodies. Science, 294(5540):178-182.
Full text not available from this repository.
View at publisher
Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are initiated by extracerebral exposure to prions. Although prion transmission from extracerebral sites to the brain represents a potential target for prophylaxis, attempts at vaccination have been limited by the poor immunogenicity of prion proteins. To circumvent this, we expressed an anti-prion protein (anti-PrP) mu chain in Prnp(o/o) mice. Transgenic mice developed sustained anti-PrP titers, which were not suppressed by introduction of Prnp+ alleles. Transgene expression prevented pathogenesis of prions introduced by intraperitoneal injection in the spleen and brain. Expression of endogenous PrP (PrP(C)) in the spleen and brain was unaffected, suggesting that immunity was responsible for protection. This indicates the feasibility of immunological inhibition of prion disease in vivo.
0 downloads since deposited on 11 Feb 2008
0 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Date:||5 October 2001|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||27 Nov 2013 17:10|
|Publisher:||American Association for the Advancement of Science (AAAS)|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page