Weissmann, C; Raeber, A J; Montrasio, F; Hegyi, I; Frigg, R; Klein, M A; Aguzzi, A (2001). Prions and the lymphoreticular system. Philosophical Transactions of the Royal Society B: Biological Sciences, 356(1406):177-184.
Full text not available from this repository.
View at publisher
Following intracerebral or peripheral inoculation of mice with scrapie prions, infectivity accumulates first in the spleen and only later in the brain. In the spleen of scrapie-infected mice, prions were found in association with T and B lymphocytes and to a somewhat lesser degree with the stroma, which contains the follicular dendritic cells (FDCs) but not with non-B, non-T cells; strikingly, no infectivity was found in lymphocytes from blood of the same mice. Transgenic PrP knockout mice expressing PrP restricted to either B or T lymphocytes show no prion replication in the lymphoreticular system. Therefore, splenic lymphocytes either acquire prions from another source or replicate them in dependency on other PrP-expressing cells. The essential role of FDCs in prion replication in spleen was shown by treating mice with soluble lymphotoxin-beta receptor, which led to disappearance of mature FDCs from the spleen and concomitantly abolished splenic prion accumulation and retarded neuroinvasion following intraperitoneal scrapie inoculation.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Date:||28 February 2001|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||05 Apr 2016 12:20|
|Publisher:||Royal Society Publishing|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page