Montrasio, F; Cozzio, A; Flechsig, E; Rossi, D; Klein, M A; Rülicke, T; Raeber, A J; Vosshenrich, C A; Proft, J; Aguzzi, A; Weissmann, C (2001). B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 98(7):4034-4037.
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Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated transgenic prion protein knockout mice overexpressing prion protein in B lymphocytes and found that they failed to accumulate prions in spleen after i.p. inoculation. We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Date:||27 March 2001|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||05 Apr 2016 12:20|
|Publisher:||National Academy of Sciences|
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