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D' Angelo, M G; Afanasieva, T A; Aguzzi, A (2000). Angiogenesis in transgenic models of multistep carcinogenesis. Journal of Neuro-Oncology, 50(1-2):89-98.

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Abstract

The histopathology and the epidemiology of human cancers, as well as studies of animal models of tumorigenesis, have led to a widely accepted notion that multiple genetic and epigenetic changes have to accumulate for progression to malignancy. Formation of new blood vessels (tumor angiogenesis) has been recognized, in addition to proliferative capabilities and to the ability to down-modulate cell death (apoptosis), as essential for the progressive growth and expansion of solid tumors beyond microscopic sizes of about 1-2 mm in diameter. Mice overexpressing activated forms of oncogenes or carrying targeted mutations in tumor suppressor genes have proven extremely useful for to linking the function of these genes with specific tumor processes; the interbreeding of these mice let us study the extent of cooperativity between different genetic lesions in disease progression, leading to a greater understanding of multi-stage nature of tumorigenesis.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2000
Deposited On:11 Feb 2008 13:26
Last Modified:27 Nov 2013 18:27
Publisher:Springer
ISSN:0167-594X
Publisher DOI:10.1023/A:1006418723103
PubMed ID:11245284
Citations:Web of Science®. Times Cited: 5
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