UZH-Logo

Maintenance Infos

Fatal intoxication with naftidrofuryl


Koller, M F; Schmid, M; Iten, P X; Vonlanthen, B; Bär, W (2009). Fatal intoxication with naftidrofuryl. Legal Medicine, 11(5):229-233.

Abstract

A 52-year-old man was found dead in his bed. He had financial and psychosocial
problems like separation from his wife and children or unemployment due to alcoholism.
Under treatment of disulfiram he was presently abstinent from alcohol. As he had
suffered from epileptic seizures and dizziness, he received valproic acid and the
vasodilator naftidrofuryl, respectively. Autopsy showed no morphologic cause of death.
Chemical analysis of blood revealed concentrations for valproic acid and disulfiram in
the therapeutic and above the therapeutic range but far below the lethal level,
respectively. No ethanol was found. However, the very high concentration of 7500 μg/L
naftidrofuryl in whole blood was considered as cause of death, and the most probable
manner of death seemed to be suicide. To our knowledge, this is the first reported case of
a fatal poisoning with naftidrofuryl.

A 52-year-old man was found dead in his bed. He had financial and psychosocial
problems like separation from his wife and children or unemployment due to alcoholism.
Under treatment of disulfiram he was presently abstinent from alcohol. As he had
suffered from epileptic seizures and dizziness, he received valproic acid and the
vasodilator naftidrofuryl, respectively. Autopsy showed no morphologic cause of death.
Chemical analysis of blood revealed concentrations for valproic acid and disulfiram in
the therapeutic and above the therapeutic range but far below the lethal level,
respectively. No ethanol was found. However, the very high concentration of 7500 μg/L
naftidrofuryl in whole blood was considered as cause of death, and the most probable
manner of death seemed to be suicide. To our knowledge, this is the first reported case of
a fatal poisoning with naftidrofuryl.

Citations

Altmetrics

Downloads

644 downloads since deposited on 25 Sep 2009
44 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Language:English
Date:September 2009
Deposited On:25 Sep 2009 08:14
Last Modified:05 Apr 2016 13:16
Publisher:Elsevier
ISSN:1344-6223
Publisher DOI:https://doi.org/10.1016/j.legalmed.2009.04.003
Permanent URL: https://doi.org/10.5167/uzh-19233

Download

[img]
Preview
Content: Accepted Version
Filetype: PDF
Size: 423kB
View at publisher
[img]
Content: Published Version
Filetype: PDF - Registered users only
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations