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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19386

Schlaefli, P; Borter, E; Spielmann, P; Wenger, R H (2009). The PAS-domain kinase PASKIN: a new sensor in energy homeostasis. Cellular and Molecular Life Sciences, 66(5):876-883.

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The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria. In yeast, the two PASKIN homologs link energy flux and protein synthesis following specific stress conditions. In mammals, PASKIN may regulate glycogen synthesis and protein translation. Paskin knock-out mice do not show any phenotype under standard animal husbandry conditions. Interestingly, these mice seem to be protected from the symptoms of the metabolic syndrome when fed a high-fat diet. Energy turnover might be increased in specific PASKIN-deficient cell types under distinct environmental conditions. According to the current model, binding of a putative ligand to the PAS domain disinhibits the kinase domain and activates PASKIN auto- and target phosphorylation. Future research needs to be conducted to elucidate the nature of the putative ligand and the molecular mechanisms of downstream signalling by PASKIN.


13 citations in Web of Science®
13 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:22 Jun 2009 14:35
Last Modified:05 Apr 2016 13:16
Funders:Wolfermann-Nägeli-Stiftung, Baugarten Stiftung/Stiftung für wissenschaftl. Forschung an der Universität Zürich, Swiss National Science Foundation
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00018-009-8699-0
PubMed ID:19189049

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