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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19393

Alberto, R (2009). The Chemistry of Technetium – Water complexes within the Manganese Triad: Challenges and Perspectives. European Journal of Inorganic Chemistry, 2009(1):21-31.

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Abstract

The chemistry of technetium is essentially driven by radiopharmaceutical
applications. These comprise the syntheses
of novel complexes but, moreover, the combination of targeting
biomolecules with metal complexes. Aqua ions are especially
convenient for facilitatating the introduction of metal
cations into biomolecules, but are nonexistent for Tc and Re
in the Mn triad. This microreview will discuss the chemistry
of those Tc complexes that contain H2O as ligands. Special
attention will be payed to organometallic aqua ions, i.e. complexes
that are typically organometallic with water as ligand.
Introduction
Among the elements of the manganese triad, the chemistry
of technetium is probably the least developed. A major
reason might be its artificial origin from nuclear fission,
and another the related radioactivity. Besides gathering fundamental
knowledge, the development of an element’s
chemistry is essentially driven by application. This statement
is supported for technetium by the very well developed
+V oxidation-state chemistry, structurally represented
by the [Tc=O]3+ moiety and stabilized by additional tetradentate
ligands. The accessibility of corresponding complexes
in one step from [TcO4]–, the exclusive starting material
for any technetium chemistry, may be a further reason.
The ultimate goal of synthetic technetium chemistry, with
radiopharmaceutical applications in mind, is the preparation
of complexes in one step directly from water. This con-
[a] Institute of Inorganic Chemistry, University of Zürich,
Winterthurerstrasse 190, 8057 Zürich, Switzerland
E-mail: ariel@aci.uzh.ch
Roger Alberto studied chemistry at the ETH Zürich, Switzerland. He received his Diploma (1982) and his Dr. sc. nat.
(1988, Prof. G. Anderegg) for research on technetium(IV) complexes from aqueous and organic solvents at the Laboratory
of Inorganic Chemistry, ETH-Zurich. As an Alexander von Humboldt fellow, he performed studies on high-valent
organometallic technetium complexes at the Technical University of Munich, TUM (Prof. W. A. Herrmann and Prof. F.
Baumgärtner) and at the Los Alamos National Laboratory (Prof. A. P. Sattelberger). From 1991 he became a senior
research scientist at the Paul Scherrer Institute (PSI), where his research on organometallic aqua ions of technetium
started. Another focus was on novel Ag, Tc and Re complexes for application in radioimmunotherapy and -diagnostics of
cancer. After further scientific visits to the TUM, and two visits to Tohoku University, Sendai Japan (Prof. K. Yoshihara,
1993/94) he earned his habilitation degree (1998, Prof. H. Berke). He received an associate Professorship in Inorganic
Chemistry (1999) and was promoted to full Professor in 2006 at the University of Zürich. His research interests focus
on inorganic medicinal chemistry, on basic technetium and rhenium chemistry in water as well as on photocatalytic H2
production.
Eur. J. Inorg. Chem. 2009, 21–31 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 21
Of particular interest is the coordination chemistry of
[M(OH2)3(CO)3]+ (M = Mn, Tc, Re) complexes in water since
it is the origin of the widely applied radiopharmaceutical research
with 99mTc and 188Re. The chemistry of organometallic
aqua ions is not confined to Werner-type ligands, hence, a
further emphasis will be placed on pure organometallic
chemistry in water.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Inorganic Chemistry
DDC:540 Chemistry
Uncontrolled Keywords:Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Date:January 2009
Deposited On:26 Jun 2009 16:52
Last Modified:27 Nov 2013 20:34
Publisher:Wiley-Blackwell
ISSN:1434-1948
Publisher DOI:10.1002/ejic.200800909
Citations:Web of Science®. Times Cited: 21
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