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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19393

Alberto, R (2009). The Chemistry of Technetium – Water complexes within the Manganese Triad: Challenges and Perspectives. European Journal of Inorganic Chemistry, 2009(1):21-31.

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Abstract

The chemistry of technetium is essentially driven by radiopharmaceutical applications. These comprise the syntheses of novel complexes but, moreover, the combination of targeting biomolecules with metal complexes. Aqua ions are especially convenient for facilitatating the introduction of metal cations into biomolecules, but are nonexistent for Tc and Re in the Mn triad. This microreview will discuss the chemistry of those Tc complexes that contain H2O as ligands. Special attention will be payed to organometallic aqua ions, i.e. complexes that are typically organometallic with water as ligand. Introduction Among the elements of the manganese triad, the chemistry of technetium is probably the least developed. A major reason might be its artificial origin from nuclear fission, and another the related radioactivity. Besides gathering fundamental knowledge, the development of an element’s chemistry is essentially driven by application. This statement is supported for technetium by the very well developed +V oxidation-state chemistry, structurally represented by the [Tc=O]3+ moiety and stabilized by additional tetradentate ligands. The accessibility of corresponding complexes in one step from [TcO4]–, the exclusive starting material for any technetium chemistry, may be a further reason. The ultimate goal of synthetic technetium chemistry, with radiopharmaceutical applications in mind, is the preparation of complexes in one step directly from water. This con- [a] Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland E-mail: ariel@aci.uzh.ch Roger Alberto studied chemistry at the ETH Zürich, Switzerland. He received his Diploma (1982) and his Dr. sc. nat. (1988, Prof. G. Anderegg) for research on technetium(IV) complexes from aqueous and organic solvents at the Laboratory of Inorganic Chemistry, ETH-Zurich. As an Alexander von Humboldt fellow, he performed studies on high-valent organometallic technetium complexes at the Technical University of Munich, TUM (Prof. W. A. Herrmann and Prof. F. Baumgärtner) and at the Los Alamos National Laboratory (Prof. A. P. Sattelberger). From 1991 he became a senior research scientist at the Paul Scherrer Institute (PSI), where his research on organometallic aqua ions of technetium started. Another focus was on novel Ag, Tc and Re complexes for application in radioimmunotherapy and -diagnostics of cancer. After further scientific visits to the TUM, and two visits to Tohoku University, Sendai Japan (Prof. K. Yoshihara, 1993/94) he earned his habilitation degree (1998, Prof. H. Berke). He received an associate Professorship in Inorganic Chemistry (1999) and was promoted to full Professor in 2006 at the University of Zürich. His research interests focus on inorganic medicinal chemistry, on basic technetium and rhenium chemistry in water as well as on photocatalytic H2 production. Eur. J. Inorg. Chem. 2009, 21–31 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim 21 Of particular interest is the coordination chemistry of [M(OH2)3(CO)3]+ (M = Mn, Tc, Re) complexes in water since it is the origin of the widely applied radiopharmaceutical research with 99mTc and 188Re. The chemistry of organometallic aqua ions is not confined to Werner-type ligands, hence, a further emphasis will be placed on pure organometallic chemistry in water.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Uncontrolled Keywords:Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Date:January 2009
Deposited On:26 Jun 2009 14:52
Last Modified:27 Nov 2013 19:34
Publisher:Wiley-Blackwell
ISSN:1434-1948
Publisher DOI:10.1002/ejic.200800909

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