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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19401

Nuvolone, M; Aguzzi, A; Heikenwalder, M (2009). Cells and prions: A license to replicate. FEBS Letters, 583(16):2674-2684 .

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Abstract

Prion diseases are neurodegenerative, infectious disorders characterized by the aggregation of a misfolded isoform of the cellular prion protein (PrP(C)). The infectious agent - termed prion - is mainly composed of misfolded PrP(Sc). In addition to the central nervous system prions can colonize secondary lymphoid organs and inflammatory foci. Follicular dendritic cells are important extraneural sites of prion replication. However, recent data point to a broader range of cell types that can replicate prions. Here, we review the state of the art in regards to peripheral prion replication, neuroinvasion and the determinants of prion replication competence.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:28 Aug 2009 14:58
Last Modified:27 Nov 2013 23:28
Publisher:Elsevier
ISSN:0014-5793
Publisher DOI:10.1016/j.febslet.2009.06.014
Official URL:http://www.febsletters.org/article/S0014-5793(09)00460-8/fulltext
PubMed ID:19527722
Citations:Web of Science®. Times Cited: 12
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