Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19402
Aguzzi, A; Steele, A D (2009). Prion topology and toxicity. Cell, 137(6):994-996.
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Abstract
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 2009 |
| Deposited On: | 23 Jun 2009 11:31 |
| Last Modified: | 23 Nov 2012 16:37 |
| Publisher: | Elsevier |
| ISSN: | 0092-8674 |
| Publisher DOI: | 10.1016/j.cell.2009.05.041 |
| PubMed ID: | 19524502 |
| WoS Citation Count: | 2 |
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