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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19402

Aguzzi, A; Steele, A D (2009). Prion topology and toxicity. Cell, 137(6):994-996.

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Abstract

Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:23 Jun 2009 09:31
Last Modified:27 Nov 2013 21:47
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/j.cell.2009.05.041
PubMed ID:19524502
Citations:Web of Science®. Times Cited: 6
Google Scholar™
Scopus®. Citation Count: 7

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