Gandy, S; DeMattos, R B; Lemere, C A; Heppner, F L; Leverone, J; Aguzzi, A; Ershler, W B; Dai, J; Fraser, P; St George Hyslop, P; Holtzman, D M; Walker, L C; Keller, E T (2004). Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development, 125(2):149-151.
Full text not available from this repository.
View at publisher
Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|Dewey Decimal Classification:||570 Life sciences; biology
610 Medicine & health
|Date:||1 February 2004|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||05 Apr 2016 12:21|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page