Gandy, S; DeMattos, R B; Lemere, C A; Heppner, F L; Leverone, J; Aguzzi, A; Ershler, W B; Dai, J; Fraser, P; St George Hyslop, P; Holtzman, D M; Walker, L C; Keller, E T (2004). Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta). Mechanisms of Ageing and Development, 125(2):149-151.
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Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). Immunized monkeys developed anti-Abeta titers exceeding 1:1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta.
|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||1 February 2004|
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||27 Nov 2013 17:20|
|Citations:||Web of Science®. Times Cited: 17|
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