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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1942

Aguzzi, A; Polymenidou, M (2004). Mammalian prion biology: one century of evolving concepts. Cell, 116(2):313-327.

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Abstract

Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a widespread health scare. On the other hand, the biology of prions represents a fascinating and poorly understood phenomenon, which may account for more than just diseases and may represent a fundamental mechanism of crosstalk between proteins. The two decades since Stanley Prusiner's formulation of the protein-only hypothesis have witnessed spectacular advances, and yet some of the most basic questions in prion science have remained unanswered.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:23 January 2004
Deposited On:11 Feb 2008 13:26
Last Modified:27 Nov 2013 18:26
Publisher:Elsevier
ISSN:0092-8674
Publisher DOI:10.1016/S0092-8674(03)01031-6
Related URLs:http://linkinghub.elsevier.com/retrieve/pii/S0092867403010316
PubMed ID:14744440
Citations:Web of Science®. Times Cited: 348
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