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Glatzel, M; Giger, Olivier; Seeger, H; Aguzzi, A (2004). Variant Creutzfeldt-jakob disease: between lymphoid organs and brain. Trends in Microbiology, 12(2):51-53.

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Abstract

Prion diseases are often caused by peripheral uptake of the infectious agent. To reach their ultimate target, the central nervous system (CNS), prions enter their host, replicate in lymphoid organs and spread via peripheral nerves. Once the agent has reached the CNS disease progression is rapid, resulting in neurodegeneration and death. many of these mechanisms have been uncovered using genetically modified mice. A recently published study demonstrated the presence of pathological prion protein in sympathetic ganglia of patients suffering from variant Creutzfeldt-Jakob disease, suggesting that these mechanisms might apply to humans.

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 February 2004
Deposited On:11 Feb 2008 12:26
Last Modified:27 Nov 2013 19:32
Publisher:Elsevier
ISSN:0966-842X
Publisher DOI:10.1016/j.tim.2003.12.001
PubMed ID:15040321

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