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Heppner, F L; Aguzzi, A (2004). Recent developments in prion immunotherapy. Current Opinion in Immunology, 16(5):594-598.

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Abstract

Antibody-based immunotherapy may represent a realistic approach against prion diseases, given that antibodies to the cellular prion protein PrPC have been shown to antagonize deposition of the disease-associated prion protein (termed PrPSc) in in vitro assays and in laboratory animals. However, induction of protective antiprion immune responses in wild-type animals is difficult because of host tolerance to the endogenous PrPC. Several studies indicate that it might be possible to overcome tolerance to PrPC and induce immune responses to bacterially expressed, recombinant PrP. However, it is much more difficult to induce antibodies capable of recognizing native cell-surface PrPC, and there is reason to believe that the latter immune responses correlate with anti-prion protection. The difficulties involved in eliciting development of such anti-native PrPC immune responses may be partly intrinsic to B cells and, in addition, may reside in peripheral T helper tolerance.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 October 2004
Deposited On:11 Feb 2008 12:26
Last Modified:27 Nov 2013 18:57
Publisher:Elsevier
ISSN:0952-7915
Publisher DOI:10.1016/j.coi.2004.07.008
PubMed ID:15342005
Citations:Web of Science®. Times Cited: 23
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