Aguzzi, A (2003). Prions and the immune system: a journey through gut, spleen, and nerves. Advances in Immunology, 81:123-171.
Full text not available from this repository.
View at publisher
For more than two decades it has been contended that prion infection does not elicit immune responses: transmissible spongiform encephalopathies do not go along with conspicuous inflammatory infiltrates, and antibodies to the prion protein are typically undetectable. Why is it, then, that prions accumulate in lymphoid organs, and that various states of immune deficiency prevent peripheral prion infection? This review revisits the current evidence of the involvement of the immune system in prion diseases, while attempting to trace the elaborate mechanisms by which peripherally administered prions invade the brain and ultimately cause damage. The investigation of these questions leads to unexpected detours, including the neurophysiology of lymphoid organs, and even the function of a prion protein homolog in male fertility.
0 downloads since deposited on 11 Feb 2008
0 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||11 Feb 2008 12:26|
|Last Modified:||27 Nov 2013 21:54|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page