Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19644
Alexander, M S; Anderson, K D; Biering-Sorensen, F; Blight, A R; Brannon, R; Bryce, T N; Creasey, G; Catz, A; Curt, A; Donovan, W; Ditunno, J; Ellaway, P; Finnerup, N B; Graves, D E; Haynes, B A; Heinemann, A W; Jackson, A B; Johnston, M V; Kalpakjian, C Z; Kleitman, N; Krassioukov, A; Krogh, K; Lammertse, D; Magasi, S; Mulcahey, M J; Schurch, B; Sherwood, A; Steeves, J D; Stiens, S; Tulsky, D S; van Hedel, H J; Whiteneck, G (2009). Outcome measures in spinal cord injury: recent assessments and recommendations for future directions. Spinal Cord, 47(8):582-591.
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Study design:Review by the spinal cord outcomes partnership endeavor (SCOPE), which is a broad-based international consortium of scientists and clinical researchers representing academic institutions, industry, government agencies, not-for-profit organizations and foundations.Objectives:Assessment of current and evolving tools for evaluating human spinal cord injury (SCI) outcomes for both clinical diagnosis and clinical research studies.Methods:a framework for the appraisal of evidence of metric properties was used to examine outcome tools or tests for accuracy, sensitivity, reliability and validity for human SCI.Results:Imaging, neurological, functional, autonomic, sexual health, bladder/bowel, pain and psychosocial tools were evaluated. Several specific tools for human SCI studies have or are being developed to allow the more accurate determination for a clinically meaningful benefit (improvement in functional outcome or quality of life) being achieved as a result of a therapeutic intervention.Conclusion:Significant progress has been made, but further validation studies are required to identify the most appropriate tools for specific targets in a human SCI study or clinical trial.Spinal Cord advance online publication, 21 April 2009; doi:10.1038/sc.2009.18.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center|
|DDC:||610 Medicine & health|
|Date:||21 April 2009|
|Deposited On:||14 Jul 2009 14:20|
|Last Modified:||23 Nov 2012 17:07|
|Publisher:||Nature Publishing Group|
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