Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1966

Aguzzi, A; Heikenwalder, M; Polymenidou, M (2007). Insights into prion strains and neurotoxicity. Nature Reviews. Molecular Cell Biology, 8(7):552-561.

[img] PDF (PDF) - Registered users only
993kB

View at publisher

Abstract

Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that are caused by prions and affect humans and many animal species. It is now widely accepted that the infectious agent that causes TSEs is PrPSc, an aggregated moiety of the host-derived membrane glycolipoprotein PrPC. Although PrPC is encoded by the host genome, prions themselves encipher many phenotypic TSE variants, known as prion strains. Prion strains are TSE isolates that, after inoculation into distinct hosts, cause disease with consistent characteristics, such as incubation period, distinct patterns of PrPSc distribution and spongiosis and relative severity of the spongiform changes in the brain. The existence of such strains poses a fascinating challenge to prion research.

Citations

119 citations in Web of Science®
121 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 11 Feb 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2007
Deposited On:11 Feb 2008 12:27
Last Modified:30 Nov 2013 17:20
Publisher:Nature Publishing Group
ISSN:1471-0072
Publisher DOI:10.1038/nrm2204
PubMed ID:17585315

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page