Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-1966
Aguzzi, A; Heikenwalder, M; Polymenidou, M (2007). Insights into prion strains and neurotoxicity. Nature Reviews. Molecular Cell Biology, 8(7):552-561.
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Transmissible spongiform encephalopathies (TSEs) are neurodegenerative diseases that are caused by prions and affect humans and many animal species. It is now widely accepted that the infectious agent that causes TSEs is PrPSc, an aggregated moiety of the host-derived membrane glycolipoprotein PrPC. Although PrPC is encoded by the host genome, prions themselves encipher many phenotypic TSE variants, known as prion strains. Prion strains are TSE isolates that, after inoculation into distinct hosts, cause disease with consistent characteristics, such as incubation period, distinct patterns of PrPSc distribution and spongiosis and relative severity of the spongiform changes in the brain. The existence of such strains poses a fascinating challenge to prion research.
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|Item Type:||Journal Article, refereed|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||11 Feb 2008 12:27|
|Last Modified:||30 Nov 2013 17:20|
|Publisher:||Nature Publishing Group|
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