Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19663

Krasnianski, A; von Ahsen, N; Heinemann, U; Meissner, B; Schulz-Schaeffer, W J; Kretzschmar, H A; Armstrong, V W; Zerr, I (2009). Increased frequency of positive family history of dementia in sporadic CJD. Neurobiology of Aging, 30(4):615-21.

[img] PDF - Registered users only
View at publisher


OBJECTIVE: To analyze whether a positive family history of dementia (PFHD) is more common in sporadic CJD (sCJD) than in healthy/population controls and to study associated risk factors. PATIENTS/METHODS: Six hundred and eighty-five sCJD patients and 659 sex-/age-matched controls were included. A PFHD in parents/grandparents/siblings was evaluated. The PRNP M129V polymorphism and ApoE genotype in sCJD with/without PFHD were determined by PCR. RESULTS: PFHD was found in 12.1% of sCJD patients and 5.6% of controls (p<0.001). No significant difference in M129V polymorphism was found between sCJD with and without PFHD. Thirty-six percent of sCJD patients with PFHD, 26% without PFHD and 19% of healthy controls had at least one ApoE4 allele. Compared to controls, ApoE4 allele frequency (p=0.005) and proportion of ApoE4 allele carriers (p=0.019) were significantly higher in sCJD with PFHD. INTERPRETATION: A higher frequency of the ApoE4 allele in sCJD with a PFHD could be indicative of an additional risk factor in CJD.


4 citations in Web of Science®
3 citations in Scopus®
Google Scholar™



0 downloads since deposited on 17 Jul 2009
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
Dewey Decimal Classification:610 Medicine & health
Date:April 2009
Deposited On:17 Jul 2009 12:50
Last Modified:05 Apr 2016 13:17
Publisher DOI:10.1016/j.neurobiolaging.2007.07.014
PubMed ID:17822808

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page