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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19711

Schulz, E; Maurer, Urs; van der Mark, S; Bucher, K; Brem, S; Martin, E; Brandeis, D (2009). Reading for meaning in dyslexic and young children: Distinct neural pathways but common endpoints. Neuropsychologia, 47(12):2544-2557.

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Abstract

Developmental dyslexia is a highly prevalent and specific disorder of reading acquisition characterised by impaired reading fluency and comprehension. We have previously identified fMRI- and ERP-based neural markers of impaired sentence reading in dyslexia that indicated both deviant basic word processing and deviant semantic incongruency processing. However, it remained unclear how specific these impairments are for dyslexia, as they occurred when children with dyslexia (DYS) were compared to chronological age-matched controls (CA) who also differ in the amount of reading experience. Adding a younger control group at a similar reading level (RL) as the dyslexic group, we examined here which of these markers would be specific for dyslexia despite matched performance, and which would resemble a developmental delay. Both the RL group and the DYS group showed a similar reversal of incongruency effects in the inferior parietal region (fMRI data) and similarly reduced incongruency effects around 400ms (ERP data) compared to the CA group, suggesting that the semantic impairment in dyslexia resembles a developmental delay. Furthermore, the DYS group showed reduced sentence reading-related activation in the inferior parietal cortex in the fMRI data, and at around 100ms (trend) and 400ms in the ERP data when compared to both CA and RL groups, suggesting dyslexia-specific deficits in basic word processing during sentence reading. Low reading skills due to young age and due to dyslexia-specific word processing deficits thus reflect different pathways which impair semantic processing in similar ways.

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11 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Center for Child and Adolescent Psychiatry
04 Faculty of Medicine > Center for Integrative Human Physiology
06 Faculty of Arts > Institute of Psychology
DDC:570 Life sciences; biology
150 Psychology
610 Medicine & health
Language:English
Date:October 2009
Deposited On:20 Jul 2009 14:58
Last Modified:14 Jul 2014 13:57
Publisher:Elsevier
ISSN:0028-3932
Publisher DOI:10.1016/j.neuropsychologia.2009.04.028
PubMed ID:19433099

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