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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19724

Hofer, M; Benden, C; Inci, I; Schmid, C; Irani, S; Speich, R; Weder, W; Boehler, A (2009). True survival benefit of lung transplantation for cystic fibrosis patients: the Zurich experience. Journal of Heart and Lung Transplantation, 28(4):334-339.

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Abstract

BACKGROUND: Lung transplantation is the ultimate therapy for end-stage cystic fibrosis (CF) lung disease; however, the debate continues as to whether lung transplantation improves survival. We report post-transplant outcome in CF at our institution by comparing 5-year post-transplant survival with a calculated 5-year survival without lung transplantation, using a predictive 5-year survivorship model, and describe pre-transplant parameters influencing transplant outcome. METHODS: CF patients undergoing lung transplantation at our center were included (1992 to 2007). Survival rates were calculated and compared, and univariate and multivariate Cox regression analyses were used for statistical assessment. RESULTS: Eighty transplants were performed in CF patients, 11 (13.8%) of whom were children. Mean age at transplant was 26.2 years (95% confidence interval: 24.4 to 28.0). The Liou raw score at transplant was -20 (95% confidence interval: -16 to -24), resulting in an estimated 5-year survival without transplantation of 33 +/- 14%, compared with a 5-year post-transplant survival of 68.2 +/- 5.6%. Further improvement was noted in the recent transplant era (since 2000), with a 5-year survival of 72.7 +/- 7.3%. Univariate analysis revealed that later year of transplant and diagnosis of diabetes influenced survival positively. Pediatric age had no negative impact. In the multivariate analysis, only diabetes influenced survival, in a positive manner. CONCLUSION: Lung transplantation performed at centers having experience with the procedure can offer a true survival benefit to patients with end-stage CF lung disease.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Endocrinology and Diabetology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Thoracic Surgery
DDC:610 Medicine & health
Language:English
Date:2009
Deposited On:14 Jul 2009 14:26
Last Modified:27 Nov 2013 19:40
Publisher:Elsevier
ISSN:1053-2498
Publisher DOI:10.1016/j.healun.2008.12.025
PubMed ID:19332259
Citations:Web of Science®. Times Cited: 24
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Scopus®. Citation Count: 27

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