Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Sherman, L; Jacoby, L B; Lampe, J; Pelton, P; Aguzzi, A; Herrlich, P; Ponta, H (1997). CD44 expression is aberrant in benign Schwann cell tumors possessing mutations in the neurofibromatosis type 2, but not type 1, gene. Cancer Research, 57(21):4889-4897.

Full text not available from this repository.


Atypical expression of CD44 splice variants has been implicated in the progression of numerous tumors. This abnormal CD44 expression is presumed to result from gene alterations that cause tumorigenic transformation. Two tumor types that have been linked to specific gene alterations are schwannomas, which have mutations in the neurofibromatosis (NF) type 2 (NF2) gene, and neurofibromas, which characteristically possess NF type 1 (NF1) gene mutations. We examined CD44 expression in normal sciatic nerves, in schwannomas with confirmed NF2 mutations, and in neurofibromas and malignant peripheral nerve sheath tumor tissue and cell lines from NF1 patients. Compared to normal nerves, schwannomas express higher total levels of CD44 and additional splice variants, whereas CD44 expression in neurofibromas is unaltered. Malignant peripheral nerve sheath tumor tissue and cell lines express the CD44v6 epitope, which is not expressed by normal Schwann cells or by other Schwann cell tumors. These data indicate that altered CD44 expression correlates strictly with mutations in the NF2 but not NF1 gene and suggest that CD44v6 might be a marker for the malignant transformation of Schwann cells.


21 citations in Web of Science®
21 citations in Scopus®
Google Scholar™

Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Feb 2008 12:27
Last Modified:05 Apr 2016 12:21
Publisher:American Association for Cancer Research
Related URLs:http://cancerres.aacrjournals.org/cgi/content/abstract/57/21/4889
PubMed ID:9354454

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page