Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Aguzzi, A; Heikenwalder, M (2006). Pathogenesis of prion diseases: current status and future outlook. Nature Reviews. Microbiology, 4(10):765-775.

Full text not available from this repository.

Abstract

The prion, a conformational variant of a host protein, is the infectious particle responsible for transmissible spongiform encephalopathy (TSE), a fatal neurodegenerative disease of humans and animals. The principal target of prion pathology is the brain, yet most TSEs also display prion replication at extra-cerebral locations, including secondary lymphoid organs and sites of chronic inflammation. Despite significant progress in our understanding of this infectious agent, many fundamental questions relating to the nature of the prion, including the mechanism of replication and the molecular events underlying brain damage, remain unanswered. Here we focus on the unresolved issues pertaining to prion pathogenesis, particularly on the role played by the immune system.

Item Type:Journal Article, refereed
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2006
Deposited On:11 Feb 2008 12:27
Last Modified:27 Nov 2013 17:38
Publisher:Nature Publishing Group
ISSN:1740-1526
Publisher DOI:10.1038/nrmicro1492
PubMed ID:16980938
Citations:Web of Science®. Times Cited: 122
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page