Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19816
Handschin, C (2009). The biology of PGC-1alpha and its therapeutic potential. Trends in Pharmacological Sciences, 30(6):322-329.
In eukaryotes, cellular and systemic metabolism is
primarily controlled by mitochondrial activity. The peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. Furthermore, PGC-1alpha controls many of the phenotypic adaptations of oxidative tissues to external and internal perturbations. By contrast, dysregulated metabolic plasticity is involved in the etiology of numerous diseases. Accordingly, modulation of PGC-1alpha levels and activity has recently been proposed as a therapeutic option for several pathologies. However, pharmacological interventions aimed at PGC-1alpha have to overcome inherent limitations of targeting a coactivator protein. Here, I focus on the recent breakthroughs in the identification of physiological and pathophysiological contexts involving PGC-1alpha. In addition, perspectives regarding the therapeutic importance of PGC-1alpha controlled cellular and systemic metabolism are outlined.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > Center for Integrative Human Physiology|
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||14 May 2009|
|Deposited On:||21 Jul 2009 15:13|
|Last Modified:||27 Nov 2013 20:57|
|Citations:||Web of Science®. Times cited: 28|
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