Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19831
Baumann, C R; Stocker, R; Imhof, H G; Trentz, O; Hersberger, M; Mignot, E; Bassetti, C L (2005). Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury. Neurology, 65(1):147-149.
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Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine|
|DDC:||610 Medicine & health|
|Deposited On:||16 Sep 2009 11:52|
|Last Modified:||27 Nov 2013 23:33|
|Publisher:||American Academy of Neurology|
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