Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-19838
Speich, R; Nicod, L P; Aubert, J D; Spiliopoulos, A; Wellinger, J; Robert, J H; Stocker, R; Zalunardo, M; Gasche-Soccal, P; Boehler, A; Weder, W (2004). Ten years of lung transplantation in Switzerland: results of the Swiss Lung Transplant Registry. Swiss Medical Weekly, 134(1-2):18-23.
View at publisher
OBJECTIVE: Lung transplantation has evolved from an experimental procedure to a viable therapeutic option in many countries. In Switzerland, the first lung transplant was performed in November 1992, more than ten years after the first successful procedure world-wide. Thenceforward, a prospective national lung transplant registry was established, principally to enable quality control. PATIENTS: The data of all patients transplanted in the two Swiss Lung Transplant centres Zurich University Hospital and Centre de Romandie (Geneva-Lausanne) were analysed. RESULTS: In 10 years 242 lung transplants have been performed. Underlying lung diseases were cystic fibrosis including bronchiectasis (32%), emphysema (32%), parenchymal disorders (19%), pulmonary hypertension (11%) and lymphangioleiomyomatosis (3%). There were only 3% redo procedures. The 1, 5 and 9 year survival rates were 77% (95% CI 72-82), 64% (95% CI 57-71) and 56% (95% CI 45-67), respectively. The 5 year survival rate of patients transplanted since 1998 was 72% (95% CI 64-80). Multivariate Cox regression analysis revealed that survival was significantly better in this group compared to those transplanted before 1998 (HR 0.44, 0.26-0.75). Patients aged 60 years and older (HR 5.67, 95% CI 2.50-12.89) and those with pulmonary hypertension (HR 2.01, 95% CI 1.10-3.65) had a significantly worse prognosis The most frequent causes of death were infections (29%), bronchiolitis obliterans syndrome (25%) and multiple organ failure (14%). CONCLUSION: The 10-year Swiss experience of lung transplantation compares favourably with the international data. The best results are obtained in cystic fibrosis, pulmonary emphysema and parenchymal disorders.
48 downloads since deposited on 16 Sep 2009
11 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Intensive Care Medicine|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||16 Sep 2009 09:16|
|Last Modified:||19 Jul 2014 06:55|
|Publisher:||EMH Swiss Medical Publishers|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page